A Bayesian framework for the analysis of systems biology models of the brain
Fig 4
Fig 4a shows the effect of different rt values on the shape of the muscular tension curve for a range of vessel radii. It can be seen that reducing rt widens the curve, leading to increased muscular tension for the same vessel radius. Figures 4b, 4c and 4d show the effect of both increasing and decreasing model inputs on cerebral blood flow for different values of rt. Cerebral blood flow (CBF) is given as a proportion of the normal CBF (40 ml 100g−1 min−1). Changing rt has a significant effect on the brain’s ability to autoregulate within the model. Fig 4b shows that higher blood pressures causes a decrease in cerebral blood flow for lower rt, as opposed to an increase at the normal value of rt = 0.018 cm. Fig 4c shows that for lower rt values, CBF decreases quicker as PaCO2 is decreased. Fig 4d shows that across all considered oxygen saturations, lower rt gives a lower CBF.