Coevolving residues inform protein dynamics profiles and disease susceptibility of nSNVs
Fig 7
Observed to expected ratio plots for disease and neutral nSNVs.
The relationship of observed-to-expected numbers between 436 disease nSNVs (red) and 302 neutral nSNVs (blue) from 139 human enzymes. The %B-factor scores derived from the Seq-GNM are binned into 5 bins of size 0.2.