Coevolving residues inform protein dynamics profiles and disease susceptibility of nSNVs
Fig 6
Comparison of theoretical B-factors on disease versus neutral mutant sites.
A ribbon diagram for two human enzymes, human lysozyme (a) and cytochrome reductase (b) colored according to their predicted B-factors by the Seq-GNM. Red indicates high mobility sites, and blue indicates low mobility sites. Each protein contains two known nSNVs. I56T and R57Q are disease-associated, and they occur on low mobility (rigid) sites. Conversely, the neutral nSNVs T116S and T70N occur on high mobility sites.