Coevolving residues inform protein dynamics profiles and disease susceptibility of nSNVs
Fig 3
Comparison of B-factors obtained by GNM and Seq-GNM with experimental B-factors.
(a) Boxplot showing the correlation of predicted B-factors by the Seq-GNM with experimentally observed B-factors (blue) in comparison to that of the GNM obtained from structure (orange) for a subset of 39 structures with resolution better than 2.0 Å. (b) A distribution plot of the same correlations binned into 10 bins with sizes of 0.1. A student t-test reveals no significant difference between the two distributions (p = 0.055) indicating that the Seq-GNM is producing competitive results compared to the original GNM from structure. The mean correlation of the Seq-GNM is 0.53 while that of the GNM from structure is 0.58.