Function and energy consumption constrain neuronal biophysics in a canonical computation: Coincidence detection
Fig 4
Trade-offs between performance and energy costs when cell morphology and membrane parameters are varied.
(A)-(E). Performance (black curves) and energy costs (blue curves) as a function of dendrite diameter (A), soma surface area (B), leak density (C), KLT density (D) and KLT activation time constant (E). Default model parameters are indicated by vertical gray bars. Stimulus is a 5 s pure tone stimulus of 500 Hz. (F) Data from panels A-E and Fig 3A plotted in the energy costs versus performance space. Performance is plotted as its reciprocal value, such that the lower, left corner gives the optimal model with high performance and low energy consumption. Default model is depicted by open star, and the pareto boundary that combines all optimal models as a thick gray curve.