Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study
Fig 6
Role of INa in transition from discordant alternans to re-entrant arrhythmias.
A(i). Snapshots of excitation waves in a homogeneous tissue with control INa. PCL = 140ms. A(ii). Time series of APs recorded from 3 different registration sites, cell A, B and C as marked by black dots in the top-left panel. B(i). Snapshots of excitation waves in a homogeneous tissue with increased INa. PCL = 140ms. B(ii). Time series of APs recorded from 3 different registration sites, cell A, B and C as marked by black dots in the top-left panel of A(i). Red arrow: marking for beginning of re-entry. Blue arrow: marking for termination of re-entry. Black and red stars marked two consecutive stimulus pulses. Simulations presented here were done with D = 0.18 mm2/ms.