Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study
Fig 5
Snapshots of conduction of AP alternans in 2D tissue and time series of APs.
APs were recorded from three different registration sites (cell A, cell B and cell C marked at the tissue shown in the top-left panel of A(i)). PCL = 140ms. A(i-ii). Tissue with reduced INa (SgNa = 0.6). B(i-ii). Control tissue (SgNa = 1.0). C(i-ii). Tissue with increased INa (SgNa = 1.5). Black and red stars marked two consecutive stimulus pulses as shown in the top-panel of A(ii), and corresponding excitation waves in the tissue (panels in A(i) and B(i) and C(i)), as well as APs recorded from the three registration sites (A(ii) and B(ii) and C(ii)).