Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study
Fig 4
Role of INa in alternans conduction in the 1D tissue model.
A. Reduced INa (SgNa = 0.6) leading to discordant alternans and conduction block with PCL = 140ms. B. Control INa (SgNa = 1.0) leading to discordant alternans with PCL = 140ms; C. Increased INa (SgNa = 1.5) leading to discordant alternans and conduction block with PCL = 140ms. D. Concordant alternans generated in control INa (SgNa = 1.0) with PCL = 150ms. E. Map of genesis of concordant, discordant and conduction block in the PCL-SgNa parameter space. F. Computed DI between two consecutive excitation waves at the marked beats and locations for generation of conduction break in (A-C).