Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study
Fig 2
1D simulation results with an altered INa.
Results were obtained by implementing three SgNa values (SgNa = 0.6, 1.0, 1.5), mimicking a reduced INa, control and an increased INa respectively. A(i). Computed PCL-dependent steady-state CV. A(ii). Maximal and averaged differences of CV between the fast and slow AP propagation during the range of PCLs producing conduction alternans. B(i). CV restitution curve computed by using the S1-S2 protocol. B(ii). The maximum slope of the CV restitution curve as shown in Fig B(i).