Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study
Fig 1
Cellular model properties with an altered INa.
Results were obtained by implementing three SgNa values (SgNa = 0.6, 1.0, 1.5), mimicking a reduced INa, control and an increased INa respectively. A(i-ii). Representative AP alternans generated by modified rabbit EPI cell model. B. Recorded INa current traces during AP alternans. C. Recorded ICaL current traces during AP alternans. D. Steady-state APD variations dependent on PCLs. E-F. The maximum and average differences of APD (E) and dV/dtmax (F) between the large and small AP during the range of PCLs that the model alters. G. ERP variations dependent on PCLs. H. APD restitution curves using S1-S2 protocol of the single cell models. I. The maximum slopes of the APD restitution curves in (H). DI: diastolic interval; PCL: pacing cycle length.