A multiscale model of epigenetic heterogeneity-driven cell fate decision-making
Fig 7
Effect of the different reprogramming strategies of blue cluster DERSs, as evaluated in terms of the statistics of the differentiation time (τD).
(a) Two step reprogramming is illustrated by the green square (first step), which finally becomes the red square (second step). One step reprogramming is depicted as the red diamond (see Section Ensemble-based strategies for unlocking resilient pluripotency for details). (b) Comparison of τD for the original DERS and the ones resulting from the reprogramming strategies. We consider a base-line scenario where the number of HMEs is exactly equal to average, i.e. eHDM = eHDAC = Z. We then compare the simulation results obtained for different scenarios regarding the different strategies to the base-line scenario. Parameter values: Z = 5 and Y = 15. Other parameter values given in S6 Table.