A multiscale model of epigenetic heterogeneity-driven cell fate decision-making
Fig 4
Scatter plots showing heterogeneity in the behaviour of bistable (a)differentiation ER systems (DERSs) and (b)pluripotency ER systems (PERSs).
The vertical axis corresponds to the average opening time and the horizontal axis, to the average closing time. Each dot in plot (a) represents a DERS within the ensemble (see Section ER-system ensemble generation and parameter sensitivity analysis). We analyse a total of 90 DERS parameter sets and 100 PERSs. The red cluster includes 31 sets, the green cluster contains 13 sets, and the blue cluster has 46 sets. Different colours and black lines show the three clusters resulting from a k-means analysis discussed in Sections Co-factor heterogeneity gives rise to both pluripotency-locked and differentiation-primed states and Analysis of ensemble heterogeneity. Dots in plot (b) represent PERSs within the ensemble defined in Section ER-system ensemble generation and parameter sensitivity analysis.