A multiscale model of epigenetic heterogeneity-driven cell fate decision-making
Fig 3
Phase diagram of the two-gene system, Eqs (5) and (6).
Vertical blue (horizontal green) hatching denotes regions where the pluripotency (differentiated) state is stable. Diagonal pink hatching denotes regions where the undecided state is stable. Regions of the phase diagram where different hatchings overlap correspond to regions of bistability or tristability. In the labels in the plot, P stands for pluripotency, D stands for differentiation and U for undecided. This phase diagram was obtained using the methodology formulated in [57]. Parameter values: ω11 = ω21 = 4.0. Other parameter values as per S7 Table.