Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors
Fig 7
(A—C) Comparison of growth curves from axial simulations of tumor cells between the Warburg effect and Glutamine addiction when 1, 3 and 5 layers of stromal cells are imposed in between the source and tumor cells, respectively. Note differences in vertical scales on plots. Each time point represents the average of 11 simulations; error bars represent standard deviation. (D) Comparison of growth rate of tumor cells at early and late times (see Methods). (E) Concentration fields of metabolites in the case of 5 layers of stromal cells at t = 0.