Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors
Fig 6
(A-C) Comparison of growth curves from axial simulations of tumor cells between the Warburg effect (WN = 2) and Reverse Warburg effect when 1, 3 and 5 layers of hijacked stromal cells are seeded between the source and tumor cells. Each time point represents the average of 11 simulations; error bars represent standard deviation. Note differences in vertical scales on plots. (D) Comparison of growth rate of tumor cells at early and late times, extracted from the average growth curves in (A-C). (E) Concentration fields of metabolites in the case of 5 layers of stromal cells at t = 0.