Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors
Fig 5
(A-C) Comparisons of growth curves from axial simulations as in Fig 4A for Warburg tumor cells with Warburg Number, WN = 0 (Control), 2, 10, and 34 with 1, 3 and 5 layers of stromal cells on top. Each time point represents the average of 11 simulations; error bars represent standard deviation. Note differences in vertical scales on plots. (D) Comparison of growth rate of tumor cells at early and late times (see Methods), extracted from the average growth curves in (A-C). (E) Concentration fields of metabolites in the case of 5 layers of stromal cells at t = 150 days. (F) Krogh lengths of oxygen and glucose based on consumption of tumor cells vs. Warburg Number. Solid line: Oxygen. Dotted line: Glucose.