Modeling driver cells in developing neuronal networks
Fig 2
The same driver LC cell upon different stimulations can enhance or depress the population activity.
The left column (x.E) refers to experimental measurements taken in slices of entorhinal cortex, while the right column (x.S) to the numerical results. Panels are similar to Fig 1 but reporting the case in which the network acceleration (a-c.E and a-c.S) and slowing down (d-f.E and d-f.S) are observable by stimulating the same neuron at different frequencies. The experiment and the simulation refer to neurons with zero functional out-degree. Experiment. Panels (a-c.E) ((d-f.E)) are obtained with νS = 0.33 Hz (νS = 1.0 Hz). Namely, the average IGI varied from 6.08 s in control conditions to 5.14 s during stimulation with νS = 0.33 Hz, and from 5.36 s to 6.68 s with νS = 1.0 Hz. Model. All the panels refer to the driver LC cell el3 connected in output to the el1 neuron discussed in panels (b-d.E) in Fig 1. The results refer to the stimulation of the same neuron with two different currents, namely panels (a-c.S) refer to Istim = 15.42 mV and (d-f.S) to current Istim = 15.9 mV.