Comprehensive computational modelling of the development of mammalian cortical connectivity underlying an architectonic type principle
Fig 11
Number and relation of neurogenetic and architectonic gradients.
A synthesis of all the results presented here indicates that the presence of two origins of neurogenesis, resulting in two neurogenetic (temporal) and architectonic gradients is necessary for the closer correspondence of the in silico model to the empirical relations between connectivity and architectonic differentiation. Importantly, the empirically observed relations are replicated in silico only if the less-to-more differentiated architectonic gradients align with early-to-late ontogenetic gradients. Hence, the suggested mechanism is consistent with correspondence of neurogenesis and architectonic differentiation [36, 37, 40] and a dual origin of the cerebral cortex [38, 71].