Computational discovery of dynamic cell line specific Boolean networks from multiplex time-course data
Fig 2
Breast cancer signaling pathway.
This figure shows the reconstructed signaling network from a combination of databases. An arrow shows the positive regulatory relationship between two proteins, while a T shaped arrow indicates inhibition. Green nodes are stimuli, blue nodes are readouts, white nodes are unmeasured or unobserved, and blue nodes with a red border represent inhibitors and readouts at the same time. Please note that in the node labels, we have added the phosphorylation sites to the protein names in order to connect them to the experimental measurements.