A Kirchhoff-Nernst-Planck framework for modeling large scale extracellular electrodiffusion surrounding morphologically detailed neurons
Fig 5
Ion concentration dynamics at selected measurement points.
The locations of the measurement points were in the ECS near the soma (green) and apical dendrites (purple) of the neuron. Δc(t) is the change in concentration from the initial value, defined as Δc(t) = c(t) − c(0). (A)-(B) Dynamics of all ion species as predicted by the KNP-scheme. (C)-(F) A comparison between the KNP and DO predictions at the measurement point near the soma. (G)-(J) A comparison between the KNP and DO predictions at the measurement point near the apical dendrites. (C)-(J) To generate the DO predictions, we set the ECS field to zero, which ensured that the ECS dynamics was due to diffusion only.