A Kirchhoff-Nernst-Planck framework for modeling large scale extracellular electrodiffusion surrounding morphologically detailed neurons
Fig 4
(A)-(D)The change in ionic concentration for Ca2+, K+, Na+, and X−, respectively, as measured at t = 80 s, compared to the initial concentration.
Δck is the change in concentration from the initial value, defined as Δck = ck(t) − ck(0). The concentrations were measured in a 2-D slice going through the center of the computational mesh, and the neuron morphology was stenciled in. The green and purple dots signify selected measurement points in the ECS near the soma (green) and apical dendrites (purple) of the neuron, which are reference points for the analysis in the following sections.