meaRtools: An R package for the analysis of neuronal networks recorded on microelectrode arrays
Fig 6
Celf4-/- neurons show elevated network synchronization phenotypes.
A) Spike frequency in bursts for Celf4+/+ (blue) and Celf4-/- (red) neural networks. B) Mutual information between electrodes is increased in Celf4-/- networks (red). C) The percent of spikes participating in NBs is increased in Celf4-/- neurons (red), suggesting that ratio of spikes that participate in synchronized network events is higher in the Celf4-/- networks. D) Raster plots show NSs (vertical green lines) and bursts (horizontal red lines) for two adjacent wells: a Celf4-/- well (upper panel) and a Celf4+/+ well (lower panel). Celf4-/- exhibits few sporadic spikes between highly synchronized events, while Celf4+/+ exhibits less network events and more sporadic spikes. Raster plots present 60 seconds of 900 seconds recordings.