Exploring the impact of inoculum dose on host immunity and morbidity to inform model-based vaccine design
Fig 8
Inoculum dependent protection and damage for the HPIV infection model.
Protection was determined based on antibody levels predicted by the model and computed using the equation for protection, P(A), described above. Morbidity was determined from the innate response levels predicted by the model and computed using the MAUC equation described above. To allow for better comparison with protection, we also scaled the MAUC values by their maximum.