In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability
Fig 8
High drug affinity ratio and large vessel poresize increases delivery efficacy potential.
Contour plots of the percentage of drug concentrated in the tumour, ch, as a function of vascular network structural parameters λ and δmax. Note that the common logarithm of ch is taken, as ch can vary by over a factor of 10 between the lowest and highest affinity ratios and poresize. The contours contained in the 2×2 matrix illustrates the in-silico results for two poresizes (A,B: rp = 10 nm; C,D: rp = 150 nm) and two affinities (A,C: kon = 0.005 s-1; B,D: kon = 5 s-1). See also S11 Fig for simulation results involving intermediate values of poresize and affinity.