In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability
Fig 7
Increasing drug affinity widens the window for vascular normalisation.
Contour plots of (A—D) maximum distance between adjacent vessels, δmax, and (E—H) vessel distribution convexity, λ, with respect to tumour development time and injection time. Each 2×2 matrix of contours depicts the results for two poresizes and two affinities: rp = 10 nm or 150 nm, and kon = 0.005 s-1 or 5 s-1 respectively. See also corresponding S9 and S10 Figs for simulation results involving intermediate values of poresize and affinity.