In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability
Fig 6
Vascular architecture normalisation depends on vessel poresize for low affinity but not high affinity drugs.
Line plots of (A—D) maximum distance between adjacent vessels (δmax; normalised), and (E—H) vessel distribution convexity (λ), as a function of time. Each 2×2 matrix of plots shows the in-silico predictions for two poresizes and two affinities: rp = 10 nm or 150 nm, and kon = 0.005 s-1 or 5 s-1 respectively, while each plot depicts the results for the control and the treated, with drug injected at day 10 (D10), day 20 (D20) or day 30 (D30). See also S7 and S8 Figs for simulation results involving intermediate values of poresize and affinity.