In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability
Fig 5
THP and IFP normalisation depends on vessel poresize for low affinity but not high affinity drugs.
Line plots of (A—D) tissue hydrostatic pressure (THP), and (E—H) interstitial fluid pressure (IFP), as a function of time. Each 2×2 matrix of plots shows the results two poresizes and two affinities: rp = 10 nm or 150 nm, and kon = 0.005 s-1 or 5 s-1 respectively. Each line plot shows the in-silico predictions for the control and the treated, with drug injected at day 10 (D10), day 20 (D20) or day 30 (D30). See also S5 and S6 Figs for simulation results involving intermediate values of poresize and affinity. Negative THP in (A—D) denotes compressive stress.