In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability
Fig 3
Tumour regression depends on vessel poresize for low affinity but not high affinity drugs.
Line plots of the relative tumour volume (V = Vol.(t)/Vol.(t = 0)−1) versus time. The 2×2 matrix of plots shows the results for two poresizes (A,B: rp = 10 nm; C,D: rp = 150 nm) and two affinities (A,C: kon = 0.005 s-1; B,D: kon = 5 s-1). Each line plot depicts the control (no drug injected), and the in-silico predictions with drug injected at day 10 (D10), day 20 (D20) or day 30 (D30). See also S4 Fig for simulation results involving intermediate values of poresize and affinity.