Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling
Fig 2
GDP- and GTP-bound systems exhibit distinctly different dynamics.
The extreme movements of the principal components PC1 and PC2 in all (A, B) GDP systems and (C, D) GTP systems. Color coding: residue 12 (orange), switch-I (residues 30–40, red), and switch-II (residues 58–72, blue).