Evolutionary footprint of epistasis
Fig 7
Examples of epistatic network.
Filled and open circles denote mutated and wild-type genomic sites, respectively. Epistatic interactions between sites are shown by black and red lines. Red lines show clusters of mutated sites. ki is the number of the cluster with i sites, bi is the bond number per cluster. Different topologies correspond to a) isolated pairs, b) isolated triple arches, where each site has two epistatic partners, c) double arches, where three sites are involved in two epistatic associations, d) long connected chain where each site forms two pairs, (a-d) show connection topology but not the actual site order. (e) Binary tree: possible site order and the equivalent tree structure.