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The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

Fig 3

Model optimization.

Typical optimization results for cAC pyramidal cells (top) and interneurons (bottom). The top left graph of each panel shows a few examples of model traces from three individuals during a current injection of -0.4, 0.4, and 0.8 nA (black, red, and blue traces, respectively). The right graph of each panel reports the objective scores for the best individual. The bottom left graph in each panel shows a typical evolution of the total score during an optimization run.

Fig 3

doi: https://doi.org/10.1371/journal.pcbi.1006423.g003