Inter-nucleosomal communication between histone modifications for nucleosome phasing
Fig 3
Visualization of H2A.Z and H4K20me1’s gene-wise positive association and nucleosome-wise negative association.
(a) Nucleosome and H4K20me1/H2A.Z profiles around -2000 ~ +2000 bp of the TSS regions. TSSs are decreasingly ranked by transcription levels, and evenly divided into 10 groups. (b) Comparison between normalized H4K20me1 (green) and H2A.Z (red) profiles around TSSs. Raw nucleosome profiles (grey) are shown. (c) H4K20me1/H2A.Z correlation for “+1” nucleosome versus surrounding nucleosomes along TSS downstream. For each group, the cross-TSS PCC between “+1” and “+2”, “+3”, …, “+10” nucleosomes were calculated with each bin of 100 TSSs respectively. See S5 Fig for more illustration on different nucleosomes. (d) Same as (c), but for H2A.Z/H4K20me1 correlation for “-1” nucleosome versus surrounding nucleosomes along TSS upstream.