Co-evolution networks of HIV/HCV are modular with direct association to structure and function
Fig 7
Immunological significance of HIV Gag sectors obtained using RoCA.
Association of HIV Gag sectors inferred using RoCA to the epitope residues targeted by T cells of (A) HIV LTNP and (B) HIV RP. The list of residues targeted by the T cells of LTNP and RP patients is provided in S1 Table. The vertical axis of each plot shows the statistical significance of the association, measured as − log10 P, where P is the P-value computed using Fisher’s exact test. The black dashed line corresponds to the conventional threshold of statistical significance, P = 0.05; any value above this line is considered statistically significant.