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Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K

Table 3

Model reproduces the experimentally documented effects of Plk1 knockdown and p110/PI3K/AKT1 over-expression / hyperactivity.

doi: https://doi.org/10.1371/journal.pcbi.1006402.t003