Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K
Fig 7
The strength of Plk1 inhibition sets the relative prominence of cell cycle failure modes.
Stacked bar charts showing the relative occurrence of normal cell cycle completion (mustard), G2 → G1 reset followed by genome duplication (purple), aberrant mitosis followed by genome duplication (turquoise), failed cytokinesis followed by genome duplication (blue) and apoptosis (dark red) relative to the rate of cell cycle in wild-type cells (black dashed line) at growth factor exposure of 40%, 60% and 80% in Plk1-deficient cells using synchronous (top) and biased asynchronous update (bottom).