Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K
Fig 4
Module-level switches toggle each other to generate the cell cycle, locking PI3K oscillations to the rhythm of division.
Dynamics of regulatory molecule expression / activity during cell cycle entry from G0, showcasing the phase-locking of PI3K oscillations to the cell cycle. X-axis: time-steps; y-axis: nodes of the model organized in modules; orange/blue: ON/OFF; white boxes & arrows: first two peaks of AKT1 activation with respect to DNA replication; black dashed lines: cytokinesis; lime arrows: first AKT1-high pulse in each division cycle.