Comparative structural dynamic analysis of GTPases
Fig 6
Mutations of common residue-wise determinants of structural dynamics between L3 and α5 have similar effects in Ras, Gαt and EF-Tu.
Mutations D47A/E49ARas in L3 (A) and R164ARas in α5 (D) significantly reduce the couplings between PL and SI. The counterpart mutations in Gαt and EF-Tu, K188AGαt in L3 (B), D337AGαt in α5 (E), R75AEF-Tu in L3 (C) and D207AEF-Tu in α5 (F) have similar effects in the nucleotide-binding region–significantly reducing the couplings between PL, SI and SII.