Comparative structural dynamic analysis of GTPases
Fig 5
Mutations of common residue-wise determinants of structural dynamics between SII and α3 have similar effects in Ras, Gαt and EF-Tu.
Mutations M72ARas in SII (A) and V103ARas in α3 (D) significantly reduce the couplings between PL and SI. The counterpart mutations in Gαt and EF-Tu, F211AGαt in SII (B), F255AGαt in α3 (E), I93AEF-Tu in SII (C) and V126AEF-Tu in α3 (F) have similar effects in the nucleotide-binding region–significantly reducing the couplings between PL, SI and SII.