Comparative structural dynamic analysis of GTPases
Fig 4
Correlation network analysis reveals similar patterns of nucleotide-dependent couplings in Ras, Gαt and EF-Tu.
(A) Network communities are represented as colored circles with different radius indicating the number of residues within the community. The width of an edge is determined by the summation of all residue level correlation values between two connected communities. Red and green edges indicate enhanced GTP or GDP couplings that are significantly (p-value < 0.05) or more than two-fold stronger in one state than the other. All other lines are colored gray. Dashed lines with a light gray background represent the two-lobe substructures. (B & C) Similar nucleotide-associated network patterns are evident in the GTP (top) and GDP (bottom) bound state of Gαt (B) and EF-Tu (C), except for the SI and SII coupling.