Activation of the DNA-repair mechanism through NBS1 and MRE11 diffusion
Fig 3
Distribution for the first passage times of NBS1 protein.
A: The blue histogram shows the first passage times of NBS1 obtained by simulations. The red line shows the approximation for fast diffusion, and the green line shows the theoretical approximation for slow diffusion theory. None of the distributions fits the entire spectrum of the first hitting times for NBS1. B: The blue histogram shows the simulated first passage time of fast NBS1 recruitment by the nucleus and the red line shows the theoretical probability distribution for the first hitting time, which follows from Eq (18). The faded area marks the time interval outside the validity of the theoretical approximation. C: The blue histogram shows the slow first passage time of NBS1 being recruited to the nucleus and the green line shows the theoretical probability distribution for the slow first hitting time, predicted using Eq (14). The faded area marks the time interval outside the validity of the theoretical approximation.