Activation of the DNA-repair mechanism through NBS1 and MRE11 diffusion
Fig 2
Sketch of the studied cell model.
The outer shell has a radius R = 25 μm, and the outer membrane is modelled through reflective boundary conditions. MRE11 and NBS1 is modelled as a Brownian particle and is initially made by the ribosome which is placed at a radial distance within Δr0 which is within the range 11-20 μm away from the center of the nucleus. The nucleus has a radius of ra = 5 μm, and is modelled as an absorbing sphere due to the nuclear pore complexes on its surface.