Activation of the DNA-repair mechanism through NBS1 and MRE11 diffusion
Fig 1
Flow diagram of the DNA-repair process.
A: The average time of MRE11, NBS1 or RAD50 getting recruited to the DNA-damage site is denoted t* and consists of the characteristic time of all three of MRE11, RAD50 and NBS1. The different activation rate constants are labelled k1−5. These processes include phosphorylation which starts protein kinase cascades. B: The broken DNA strand recruits proteins MRE11, NBS1, and RAD50 after a characteristic time, tN, tM and tR respectively. The combined recruitment time is denoted t*.