Flexible resonance in prefrontal networks with strong feedback inhibition
Fig 6
Neuromodulation of firing rate resonance in PC/IN network.
(A) Diagram showing an external sinusoidal Poisson input to the dendrites of 20 two-compartment principal cells (PCs) receiving feedback inhibition from a population of 5 fast spiking interneurons (INs). PC and IN models include conductances found in prefrontal neurons (see Fig 7A for details). (B) Input frequency-dependent firing rate profile showing resonance at a beta2 frequency. (C) The effect of knocking out individual ion currents on the resonant input frequency maximizing firing rate outputs. Removing hyperpolarizing currents (-Ks, -KCa) increased the resonant frequency, while removing depolarizing currents (-NaP) decreased the resonant frequency or (-Ca) silenced the cell altogether (see Fig 7A for ion channel key). Error bars indicate mean ± standard deviation across 10 realizations; only -KCa had a non-zero standard deviation (i.e., values that differed across realizations). (D) The effect of hyperpolarizing and depolarizing injected currents, Iapp, on the resonant frequency mirrored the effect of knockouts on excitability.