Flexible resonance in prefrontal networks with strong feedback inhibition
Fig 4
Dependence of response profiles on input synchrony.
(A) Diagram of PFC network receiving variable-synchrony square wave or sinusoidal inputs. (Bi) Firing rate profile for PC populations given oscillatory inputs with different degrees of synchrony. (Bii) Population frequency profile for inputs with different degrees of synchrony. Horizontal dashed line marks the natural frequencies for each degree of synchrony. (C) The effect of input synchrony on resonant frequencies. Maximum population frequency (at the IN firing rate res. freq.) increases with input synchrony. (D) Spike rasters and PC iFR responses showing the nesting of natural oscillations generated by a local network on the depolarizing phase of a lower-frequency external driving oscillation with sine wave (left) or square wave (right) rate-modulation. (E) Spike rasters and PC iFR responses showing that weaker firing rate resonance at the first harmonic (i.e., smaller bump at finp = 44Hz in Bi, blue curve) occurs for high synchrony (left) but not low synchrony (right) oscillatory inputs.