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Flexible resonance in prefrontal networks with strong feedback inhibition
Fig 3
Frequency-dependent suppression of asynchronous activity.
(A) Diagram showing a target PC population, PCT, driven by medium-synchrony oscillatory input in competition with an asynchronously-driven distractor PC population, PCD. (B) Dependence of distractor suppression on target input frequency. (i) Time-averaged firing rates (FRs) of PCT (blue) and PCD (black) populations. As expected, PCT FR peaks at the 
-resonant frequency. PCD responds at the FR expected given asynchronous input (horizontal black line, labeled “natural response”) when target input frequency is below the natural frequency (vertical black line) or far above 
; it is suppressed at intermediate frequencies. (ii) PCT population (output) frequency versus the input frequency to PCT. As expected, PCT fpop peaks at the fpop-resonant frequency. Importantly, whenever fpop exceeds the natural frequency (horizontal black line), PCD FR is suppressed; maximal suppression of PCD occurs when PCT fpop is maximal and not when PCT FR peaks in (i). (C) Example simulation with continuous suppression of the distractor pathway by a target pathway driven with a fpop-resonant input. On every cycle, the more rapidly oscillating target population engages the INs before the distractor reaches threshold.
doi: https://doi.org/10.1371/journal.pcbi.1006357.g003