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Discerning evolutionary trends in post-translational modification and the effect of intrinsic disorder: Analysis of methylation, acetylation and ubiquitination sites in human proteins

Fig 5

Example of a protein with methylation, acetylation and ubiquitination sites in ordered and disordered regions.

Multiple sequence alignment of human chromobox protein homolog 3 and its primate orthologs, depicted using JalView [88], showing methylation, acetylation (purple) and ubiquitination (yellow) sites in ordered (green) and disordered (peach) regions. The sites with both acetylation and methylation sites are highlighted in brown, sites with both acetylation and ubiquitination sites are highlighted in cyan and the sites with acetylation, methylation and ubiquitination sites are highlighted in red.

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1006349.g005