Rare-event sampling of epigenetic landscapes and phenotype transitions
Fig 5
The rare-event sampling pipeline makes rare states and transitions accessible to simulation.
A) The global state-transition graph computed with the computational pipeline for the Pluripotency Network with rare transitions (Parameter Set II). The states are colored according to the coarse-grained (algorithmically-identified) phenotypes. In this parameter regime (f = 50) the differentiated (TE, PE, IM) and pluripotent phenotypes are cleanly separated, reflecting exceedingly rare transitions between the two phenotypes (O(109), see Table 1). (B) States visited in conventional SSA simulation (using the same initialization, definitions, and placement as in (A)). In the conventional simulation, a transition out of the IM phenotype was never observed.