A model for hydrophobic protrusions on peripheral membrane proteins
Fig 5
’Co-insertable protruding hydrophobes’ are common in peripheral proteins and rare in the reference sets.
The plots show the occurrence of ‘co-insertable protruding hydrophobes’ on protein surfaces. Panels A-C show the comparison between the sets ‘Peripheral’ and ‘Non-binding surfaces’ and panels D-F the comparison between ‘Peripheral-P’ and ‘Reference Proteins’. Panels A, B, D, and E show the weighted fraction (Eq 5) of proteins that have protruding hydrophobes in the peripheral proteins (blue) and the reference sets (red). We differentiate here between protrusions that have at least one co-insertable protruding hydrophobe (labeled “Co-ins.”), and those that have not (labeled “isolated”). The analysis is done separately for two groups of proteins according to the total number of protrusions on the protein surface ([0, 25〉 in panels A and D, [25, 50〉 in panels B and E). Panels C and F show the frequency distribution of the total number of protruding residues (“# protrusions”) for all proteins. The selections analysed in panels A, B, D, and E are found between the dashed lines in panels C and F. Error bars in panels A, B, D, and E are 95% confidence intervals.