A model for hydrophobic protrusions on peripheral membrane proteins
Fig 4
The ‘protruding hydrophobes’ tend to be ‘co-insertable’ in peripheral proteins.
Panel A shows the comparison between the data sets ‘Peripheral’ and ‘Non-binding surfaces’, and B the comparison between the ‘Peripheral-P’ and ‘Reference Proteins’. The tendency for protrusions to be co-insertable is quantified by the weighted frequency of co-insertion (Eq 9), and is compared between each data set and a null model using the odds ratio (Eq 10). Positive values reflect higher frequencies of co-insertion than in the null model. More precisely we plot where set represents the set of peripheral proteins (blue) and the corresponding reference set (red), and null represent their respective null models where hydrophobes have been relocated randomly among protrusions as described in ‘Materials and methods’. Error bars are 95% confidence intervals.