Profiling cellular morphodynamics by spatiotemporal spectrum decomposition
Fig 6
Application of merging algorithm before, during, and after optogenetic Vav2 inhibition in two Cos7 cells with distinct initial morphodynamics.
(a) Snapshots of protruding Cos7 cells with strong (top) and weak (bottom) polarity. Scale bar = 25 μm. (b) Top: Protrusion activity map of the Cos7 cell with a strong initial polarity; Bottom: Spectral clustering result (Q = 3). (c) Top: Protrusion activity map of the Cos7 cell with weak polarity; Bottom: Spectral clustering result (Q = 3).